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Objective: to evaluate the association between quality of life and presence of symptoms of depression, anxiety, and stress in college students in the health area. Method: cross-sectional study that included 321 students from undergraduate courses in the health area. Quality of life was measured using the World Health Organization scale, abbreviated version, in the physical, psychological, social relations and environment domains, and symptoms were assessed by the depression, anxiety and stress scale. Multivariate analysis was performed using robust linear regression to evaluate the association between quality of life and symptoms. Results: a negative association was observed between the quality of life and depression symptoms in all domains, while anxiety symptoms showed a negative association in the environment domain, and stress symptoms had a negative association in the psychological domain. Symptom severity was unfavorably associated with quality of life, that is, the greater the symptom severity, the lower the mean scores in all domains. Conclusion: symptoms of depression, anxiety, and stress were prevalent and had a negative impact on students’ quality of life, especially in the presence of depressive symptoms. The decrease in scores was significantly associated with the severity of symptoms.

Objetivo: evaluar la asociación entre la calidad de vida y la presencia de síntomas de depresión, ansiedad y estrés en estudiantes universitarios del área de la salud. Método: estudio transversal que incluyó a 321 estudiantes de carreras del área de la salud. La calidad de vida se midió mediante la escala de la Organización Mundial de la Salud, versión abreviada, en los dominios físico, psicológico, relaciones sociales y ambiente, y los síntomas se evaluaron por la escala de depresión, ansiedad y estrés. Se realizó un análisis multivariante por medio de regresión lineal robusta para evaluar la asociación entre la calidad de vida y los síntomas presentados. Resultados: se observó una asociación negativa entre la calidad de vida y los síntomas de depresión en todos los dominios, mientras que los síntomas de ansiedad tuvieron una asociación negativa en el dominio ambiente, y los síntomas de estrés tuvieron una asociación negativa en el dominio psicológico. La gravedad de los síntomas se asoció desfavorablemente con la calidad de vida, es decir, cuanto mayor la gravedad de los síntomas, menores las puntuaciones medias en todos los dominios. Conclusión: los síntomas de depresión, ansiedad y estrés fueron prevalentes e impactaron negativamente en la calidad de vida de los estudiantes, especialmente en presencia de síntomas depresivos. Las puntuaciones disminuidas se asociaron significativamente con la gravedad de los síntomas.

Objetivo: avaliar a associação entre qualidade de vida e presença de sintomas de depressão, ansiedade e estresse em estudantes universitários da área da saúde. Método: estudo transversal que incluiu 321 estudantes de cursos de graduação da área da saúde. A qualidade de vida foi mensurada por meio da escala da Organização Mundial da Saúde, versão abreviada, nos domínios físico, psicológico, relações sociais e meio ambiente, e os sintomas avaliados pela escala de depressão, ansiedade e estresse. Foi realizada análise multivariada utilizando regressão linear robusta para avaliar a associação entre qualidade de vida e sintomas apresentados. Resultados: observou- se associação negativa entre qualidade de vida e sintomas de depressão em todos os domínios, enquanto os sintomas de ansiedade apresentaram associação negativa no domínio meio ambiente, e os sintomas de estresse tiveram associação negativa no domínio psicológico. A gravidade dos sintomas associou-se de forma desfavorável com a qualidade de vida, ou seja, quanto maior a gravidade dos sintomas, menor a média dos escores em todos os domínios. Conclusão: sintomas de depressão, ansiedade e estresse mostraram-se prevalentes e com impacto negativo na qualidade de vida dos estudantes, principalmente na presença de sintomas depressivos. A diminuição dos escores foi significativamente associada à gravidade dos sintomas.

https://doi.org/10.1590/1518-8345.6315.3884

[SciELO Preprints] - Anxiety and depression symptoms in university students from public institutions of higher education in Brazil during the covid-19 pandemic: a multicenter study
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Barbosa, Bruna Carolina Rafael Paula, Waléria de Ferreira, Aline Dayrell Freitas, Eulilian Dias de Chagas, Carolina Martins dos Santos Oliveira, Helian Nunes de Ferreira, Lívia Garcia Silva, Luciana Saraiva da Vidigal, Fernanda de Carvalho Nobre, Luciana Neri Machado, Elaine Leandro Cardoso, Clareci Silva Meireles, Adriana Lúcia

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Data de publicação: 2023-05-25

Resumo: En

This is a multicenter, cross-sectional study carried out with students regularly enrolled in undergraduate courses at eight Brazilian IFES. Data collection was conducted between October 2021 and February 2022 using an online self-completed questionnaire, which addressed sociodemographic and academic characteristics, lifestyle habits, and health conditions. Symptoms of anxiety and depression were assessed using the Depression, Anxiety, and Stress Scale-21 (DASS-21). Variables were analyzed descriptively using frequency distribution and Pearson’s chi-square test. To estimate the prevalence of symptoms of anxiety and depression, the proportion and 95% confidence interval (95%CI) were used. The level of adopted statistical significance was 5%.

https://doi.org/10.1590/SciELOPreprints.6080

[SciELO Preprints] - VACCINATION CARD: IMPORTANT INSTRUMENT TO STIMULATE THE VACCINATION AUTONOMY OF STUDENTS
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Paula, Rayan Silva de Monteiro, Adriana Maira Ferreira Cardoso Reis, Deyse Almeida dos

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Data de publicação: 2023-04-13

Resumo: En Es Pt

Due to the decrease in adherence to vaccination and strengthened by the anti-vaccination movement, world vaccination coverage is at a low level and there is a recirculation of once eradicated diseases. In Brazil, recognized for its successful campaigns to vaccinate childrenand adolescents, the valid document for measuring vaccination coverage is the vaccination card (VC). However, there is a gap between subjects and their VCs, in which deterioration and misplacement of this document are recurrent. Thus, the present study proposed the application of a didactic sequence involving aspects of vaccination, in order to stimulate the vaccinal autonomy of students in a public school. Theoretical classes were taught; exhibition of the animation “Cells at Work!”; and carried out practices with the VC of the students themselves. Among the participants, 88.24% and 82.35% showed, respectively, understanding that the cells of the immune system act through phagocytosis and the production of antibodies. 76.47% understood that vaccines provide individual and collective protection and 64.71% that the VC allows monitoring the individual's vaccination status. Among the vaccines consulted, most were vaccinated against polio, measles and Covid-19, and for this last vaccine, everyone had taken at least the first dose. Surprisingly, 78.57% stated that they had already had access to their VV, however only 28.57% had considered the information contained therein. Finally, 92.86% stated that they needed to check and update the VC and felt compelled to keep the VC in accordance with the national vaccination schedule, showing the awareness of these students' vaccinal autonomy.

Debido a la disminución de la adherencia a la vacunación y fortalecida por el movimiento antivacunación, la cobertura mundial de vacunación se encuentra en un nivel bajo y existe una recirculación de enfermedades erradicadas. En Brasil, reconocido por sus exitosas campañas de vacunación de niños y adolescentes, el documento válido para medir las coberturas de vacunación es la cartilla de vacunación (CV). El presente estudio propuso la aplicación de una secuencia didáctica que involucra aspectos de vacunación, con el fin de estimular la autonomía vacunal de los alumnos. Se impartieron clases teóricas; se mostró la animación “Cells at Work!”; y las prácticas se realizaron con las CVs de los propios alumnos. Entre los participantes, el 88,24% y el 82,35% mostraron, respectivamente, comprender que las células inmunitarias actúan por fagocitosis y la producción de anticuerpos. El 76,47% entendió que las vacunas brindan protección individual y colectiva y el 64,71% que la CV permite monitorear el estado vacunal del individuo. Entre las vacunas, la mayoría estaban vacunadas contra la poliomielitis, el sarampión y el Covid-19 (en las que todos habían tomado al menos la primera dosis). Sorprendentemente, el 78,57% afirmó que ya había tenido acceso a su CV, sin embargo, solo el 28,57% había considerado la información contenida en la CV. Finalmente, el 92,86% afirmó que necesitaba revisar y actualizar la CV y se sintió obligado a mantener la CV de acuerdo con el calendario nacional de vacunación, lo que demuestra la conciencia de la autonomía vacunal de estos estudiantes.

Devido à diminuição da adesão à vacinação e fortalecidos pelo movimento antivacina, a cobertura vacinal mundial encontra-se em baixa e observa-se a recirculação de doenças outrora erradicadas. No Brasil, reconhecido por suas campanhas bem-sucedidas para vacinação de crianças e adolescentes, o documento válido para aferimento da cobertura vacinal é o cartão de vacinação (CV). Todavia, observa-se um distanciamento entre sujeitos e seus CVs, em que deterioração e extravios desse documento são recorrentes. Assim, o presente estudo propôs a aplicação de uma sequência didática envolvendo aspectos da vacinação, a fim de estimular a autonomia vacinal de estudantes de uma escola pública. Foram lecionadas aulas teóricas; exibidos episódios da animação “Cells at Work!”; e realizadas práticas com CVs dos próprios estudantes. Dentre os participantes, 88,24% e 82,35% mostraram, respectivamente, compreender que as células do sistema imunológico atuam por meio da fagocitose e da produção de anticorpos. 76,47% compreenderam que as vacinas conferem proteção individual e coletiva e 64,71% que o CV permite acompanhar o estado vacinal do indivíduo. Dentre as vacinas consultadas, a maioria era vacinada contra poliomielite, sarampo e Covid-19, sendo que para essa última vacina, todos haviam tomado pelo menos a primeira dose. Surpreendentemente, 78,57% afirmaram que já tinham tido acesso a seu CV, entretanto apenas 28,57% havia atentado às informações ali contidas. Por fim, 92,86% afirmaram que necessitam checar e atualizar o CV bem como se sentem impelidos a manter o CV em acordo com o calendário nacional de vacinação, evidenciando o despertar quanto à autonomia vacinal desses estudantes.

https://doi.org/10.1590/SciELOPreprints.5903

Behçet’s disease as a differential diagnosis of acute genital ulcer: a case report Behçets Behçet s ulcer
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Marchetti, Giulia

; Cardoso-Vasquez, Iramaia

; Bittencourt-Campaner, Adriana

Portuguese Journal of Dermatology and Venereology

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Mar 2023, Volume 81 Nº 1 Páginas 53 - 56

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Acute genital ulcers (AGU) have numerous etiologies and are a frequent complaint in the emergency room. Its diagnosis is mostly clinical and initially approached in a syndromic manner. It is based on history, physical examination, and laboratory findings. It is known that genital ulcer can be the first manifestation of Behçet’s disease (BD) and its early recognition can prevent clinical complications related to the disease and improve the patient’s quality of life. The present article aims to report the case of a patient with an extensive and deep ulcerative lesion of the vulva, who was initially treated with acyclovir due to the suspicion of genital herpes. Subsequently, after the condition worsened and when adequate anamnesis was collected, diagnostic criteria for BD were identified and the correct treatment was started, with therapeutic success. From the above, it is essential that the gynecologist focuses on BD as one of the differential diagnoses for acute genital ulcer. AGU (AGU room manner history examination findings Behçets Behçet s (BD patients life vulva herpes Subsequently collected started success above

Resumo As úlceras genitais agudas possuem inúmeras etiologias e são uma queixa frequente de procura ao pronto socorro. Seu diagnóstico é majoritariamente clínico e inicialmente abordado de forma sindrômica. É baseado na história, exame físico e achados laboratoriais. Sabe-se que a úlcera genital pode ser a primeira manifestação da doença de Behçet e seu reconhecimento precoce pode evitar complicações clínicas relacionadas à doença, além de melhorar a qualidade de vida da paciente. O presente artigo teve como objetivo relatar caso de paciente com lesão ulcerosa extensa e profunda da vulva, que foi inicialmente tratada com acyclovir, pela suspeita de herpes genital. Posteriormente, após piora do quadro e ao coletar-se anamnese adequada, identificou-se critérios diagnósticos para doença de Behçet e iniciou-se o tratamento correto, com sucesso terapêutico. Do exposto, é fundamental que o ginecologista se atente à doença de Behçet como um dos diagnósticos diferenciais para úlcera genital aguda. socorro sindrômica história laboratoriais Sabese Sabe vulva acyclovir Posteriormente coletarse coletar adequada identificouse identificou iniciouse iniciou correto terapêutico exposto aguda

https://doi.org/10.24875/pjdv.22000020

The effect of Vitamin E supplementation on inflammatory biomarkers and oxidative stress in patients with chronic kidney disease on hemodialysis: A systematic review
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Morais de Sousa, Dallyla Jennifer

; Cardoso de Sousa, Larissa Layana

; Oliveira Barrense, Clenio

; Cardoso de Araújo, Diana Stefany

; Visgueira de Sousa, Thayanne Gabryelle

; de Azevedo Paiva, Adriana

; Silva de Almendra Freitas, Betânia de Jesus e

Revista chilena de nutrición

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Fev 2023, Volume 50 Nº 1 Páginas 117 - 126

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La hemodiálisis, junto con la enfermedad renal crónica (ERC), intensifica el proceso inflamatorio y el estrés oxidativo en los pacientes en tratamiento. En este contexto, la suplementación con vitamina E puede mitigar los efectos nocivos resultantes de estos procesos. Esta es una revisión sistemática cuyo objetivo fue evaluar el efecto de la suplementación con vitamina E sobre biomarcadores inflamatorios y estrés oxidativo en pacientes con ERC en hemodiálisis. La revisión se elaboró según la metodología para revisiones sistemáticas y metanálisis (PRISMA) y la búsqueda se realizó en las bases de datos Pubmed, Cochrane Library, Scopus y Web of Science. El riesgo de sesgo de los estudios incluidos se evaluó con la Herramienta Cochrane de Riesgo de Sesgo (Cochrane Risk of Bias Tool). En esta revisión se incluyeron doce estudios desarrollados entre 2006 y 2020. La mayoría (n= 11) utilizó dosis de vitamina E que oscilaban entre 400 UI y 888 UI y el tiempo de suplementación osciló entre 2 semanas y 12 meses. De los 12 artículos incluidos, 25% (n= 3) analizaba la suplementación en biomarcadores inflamatorios, 50% (n= 6) en biomarcadores de estrés oxidativo y 25% (n= 3) en estos parámetros simultáneamente. Se observó un efecto positivo en 58,4% de los estudios (n= 7). Por lo tanto, la suplementación con vitamina E puede ser efectiva para mitigar el proceso inflamatorio y el estrés oxidativo, sin embargo, vale la pena señalar que el efecto depende de la dosis y el tiempo de suplementación.

ABSTRACT Hemodialysis, along with chronic kidney disease (CKD), intensifies the inflammatory process and oxidative stress in patients undergoing treatment. In this context, Vitamin E supplementation can mitigate the deleterious effects resulting from these processes. This is a systematic review whose objective was to evaluate the effect of Vitamin E supplementation on inflammatory biomarkers and oxidative stress in patients with CKD on hemodialysis. This review was prepared according to the methodology for systematic reviews and meta-analyses (PRISMA) and the search was performed in Pubmed, Cochrane Library, Scopus and Web of Science databases. The risk of bias of the included studies was assessed with the Cochrane Risk of Bias Tool. Twelve studies developed between 2006 and 2020 were included in this review. Most of them (n= 11) used vitamin E doses ranging from 400 IU to 888 IU and the supplementation time ranged from 2 weeks to 12 months. Of all the 12 articles included, 25% (n= 3) analyzed supplementation on biomarkers of oxidative stress and 25% (n= 3) addressed these parameters simultaneously. A positive effect was observed in 58.4% of the studies (n= 7). Thus, Vitamin E supplementation can be effective in mitigating the inflammatory process and oxidative stress, however, it is worth noting that the effect depends on the dose and time of supplementation.

El concepto de felicidad desde el taller de diseño básico
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Cardoso Villegas, Adriana Judith

Zincografía

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2023, Volume 7 Nº 13 Páginas 186 - 201

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Se presenta la valoración de 18 composiciones bidimensionales que conceptualizaron el tema de felicidad, realizadas en el taller de diseño básico en el periodo de otoño 2021 en la licenciatura de Diseño Gráfico de la Benemérita Universidad Autónoma de Puebla (BUAP). La elección del tema surgió por la falta de entusiasmo y felicidad que estudiantes experimentaron a causa de la pandemia por COVID-19; entonces, el taller de diseño básico se promulgó como un espacio en el cual los estudiantes buscaran satisfacción, interés y felicidad con sus procesos y resultados. Las bases teóricas incluyeron la conceptualización de felicidad; también de forma, color y composición desde la teoría del diseño básico, así como los modelos de evaluación y categorización de las emociones de Watson, Tellegen y Browne (citados en Díaz y Flores, 2001) y el propuesto por Díaz y Flores (2001). El enfoque fue mixto con la fase cualitativa en la construcción visual del concepto de felicidad y la obtención de 18 composiciones bidimensionales. La fase cuantitativa empleó la encuesta con un muestreo por conveniencia a 215 respondientes que valoraron los conceptos de satisfacción, alegría y bienestar mediante la escala Likert. Al evaluar la preferencia visual y mayor asociación de los conceptos en las propuestas visuales, resultó que una de las 18 composiciones obtuvo la mayor asociación en los tres conceptos: satisfacción, alegría y bienestar, estableciendo relaciones de sintaxis visual en el uso de la forma, el color y la composición, así como en la propia conceptualización de felicidad por parte de los respondientes y de los estudiantes de Diseño Gráfico.

Abstract The evaluation of 18 two-dimensional compositions that conceptualized the theme of happiness, carried out in the basic design workshop in the autumn 2021 period in the Graphic Design degree of the Meritorious Autonomous University of Puebla (BUAP) is presented. The choice of topic arose from the lack of enthusiasm and happiness that students experienced due to the COVID-19 pandemic; then, the basic design workshop was promulgated as a space in which students sought satisfaction, interest and happiness with their processes and results. The theoretical bases included the conceptualization of happiness; also of shape, color and composition from the theory of basic design, as well as the models of evaluation and categorization of emotions by Watson, Tellegen and Browne (cited in Díaz and Flores, 2001) and the one proposed by Díaz and Flores (2001). The approach was mixed with the qualitative phase in the visual construction of the concept of happiness and obtaining 18 two-dimensional compositions. The quantitative phase used the survey with a convenience sample of 215 respondents who assessed the concepts of satisfaction, joy and well-being using the Likert scale. When evaluating the visual preference and greater association of the concepts in the visual proposals, it turned out that one of the 18 compositions obtained the greatest association in the three concepts: satisfaction, joy and well-being, establishing visual syntax relationships in the use of form, color and composition, as well as in the own conceptualization of happiness by the respondents and the Graphic Design students.

https://doi.org/10.32870/zcr.v7i13.187

Emotional, hyperactivity and inattention problems in adolescents with immunocompromising chronic diseases during the COVID-19 pandemic
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Campos, Reinan T.

; Lindoso, Livia

; Sousa, Renan A. de

; Helito, Alberto C.

; Ihara, Bianca P.

; Strabelli, Claudia A.A.

; Paradelas, Levi M.V.

; Carneiro, Beatriz O.L.

; Cardoso, Maria Paula R.

; Souza, Jean Paulo V. de

; Freire, Marianna R. de M.

; Astley, Camilla

; Laurentino, Moisés F.

; Buscatti, Izabel M.

; Kozu, Katia

; Aikawa, Nadia E.

; Sallum, Adriana M.E.

; Ferreira, Juliana CO.

; Simon, Juliana R.

; Viana, Vivianne S.L.

; Queiroz, Ligia B.

; Gualano, Bruno

; Roschel, Hamilton

; Pereira, Rosa Maria R.

; Toma, Ricardo K.

; Watanabe, Andréia

; Grangeiro, Patricia M.

; Casella, Caio B.

; Farhat, Sylvia C.

; Polanczyk, Guilherme V.

; Campos, Lucia Maria A.

; Silva, Clovis A.

Clinics

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2023, Volume 78 elocation 100167

Resumo: En | Texto: En | PDF: En

Abstract Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics.

https://doi.org/10.1016/j.clinsp.2023.100167

A case-control study of Clostridioides difficile symptomatic infections in a pediatric cancer hospital
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Silva, Adriana Maria Paixão de Sousa da

; Barbosa, Lara de Castro

; Marques, Leticia Maria Acioli

; Carreira, Letícia Yasuda

; Fonseca, Fernanda Maria Casimiro da

; Lima, Ana Paula Cordeiro

; Sodré, Janaína Joice Martins

; Pignati, Luara Teofilo

; Araújo, Orlei Ribeiro

; Silva, Dafne Cardoso Bourguignon da

; Carlesse, Fabianne Altruda de Moraes Costa

Revista Paulista de Pediatria

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2023, Volume 41 elocation e2022117

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Objective: The aim of this study was to analyze and identify documented infections and possible risk factors for Clostridioides difficile infections in children with cancer. Methods: This is a retrospective case-control study, carried out in a pediatric cancer hospital, covering the years 2016–2019. Matching was performed by age and underlying disease, and for each case, the number of controls varied from 1 to 3. Logistic regression models were used to assess risk factors. Results: We analyzed 63 cases of documented infection by C. difficile and 125 controls. Diarrhea was present in all cases, accompanied by fever higher than 38°C in 52.4% of the patients. Mortality was similar among cases (n=4; 6.3%) and controls (n=6; 4.8%; p=0.7). In all, 71% of patients in the case group and 53% in the control group received broad-spectrum antibiotics prior to the infection. For previous use of vancomycin, the Odds Ratio for C. difficile infection was 5.4 (95% confidence interval [95%CI] 2.3–12.5); for meropenem, 4.41 (95%CI 2.1–9.2); and for cefepime, 2.6 (95%CI 1.3–5.1). For the antineoplastic agents, the Odds Ratio for carboplatin was 2.7 (95%CI 1.2–6.2), melphalan 9.04 (95%CI 1.9–42.3), busulfan 16.7 (95%CI 2.1–134.9), and asparaginase 8.97 (95%CI 1.9–42.9). Conclusions: C. difficile symptomatic infection in children with cancer was associated with previous hospitalization and the use of common antibiotics in cancer patients, such as vancomycin, meropenem, and cefepime, in the last 3 months. Chemotherapy drugs, such as carboplatin, melphalan, busulfan, and asparaginase, were also risk factors.

RESUMO Objetivo: Analisar e identificar infecções documentadas e possíveis fatores de risco para infecções por Clostridioides difficile em crianças com câncer. Métodos: Estudo retrospectivo caso-controle em um hospital pediátrico oncológico, que abrangeu os anos de 2016–2019. O pareamento foi realizado por idade e doença de base e, para cada caso, o número de controles variou de um a três. Modelos de regressão logística foram utilizados para avaliar os fatores de risco. Resultados: Analisamos 63 casos de infecção documentados por C. difficile e 125 controles. A diarreia esteve presente em todos os casos, acompanhada de febre acima de 38°C em 52,4% dos pacientes. A mortalidade foi semelhante entre casos (n=4, 6,3%) e controles (n=6, 4,8%; p=0,7). No grupo caso, 71% dos pacientes e, no grupo controle, 53% deles receberam antibióticos de amplo espectro antes da infecção. Para uso prévio de vancomicina, a Odds Ratio para infecção por C. difficile foi de 5,4 (intervalo de confiança [IC95%] 2,3–12,5); para meropenem, 4,41 (IC95% 2,1–9,2) e, para cefepima, 2,6 (IC95% 1,3–5,1). Para os agentes antineoplásicos, a razão de chances para carboplatina foi de 2,7 (IC95% 1,2–6,2), para melfalano de 9,04 (IC95% 1,9-42,3), para bussulfano de 16,7 (IC95% 2,1–134,9) e, para asparaginase, de 8,97 (IC95% 1,9–42,9). Conclusões: A infecção sintomática por C. difficile em crianças com câncer associou-se à internação prévia e ao uso de antibióticos como vancomicina, meropenem e cefepime nos últimos três meses. Os quimioterápicos carboplatina, melfalano, bussulfano e asparaginase também foram fatores de risco.

https://doi.org/10.1590/1984-0462/2023/41/2022117

Effect of spineless cactus [Nopalea cochenillifera (L.) Salm Dyck] on nutrient intake, ingestive behaviour, and performance of lambs
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BEZERRA, SHARLENY B.L.

; VÉRAS, RÓBSON M.L.

; BATISTA, ÂNGELA M.V.

; GUIM, ADRIANA

; MACIEL, MICHEL DO V.

; CARDOSO, DANIEL B.

; LIMA JÚNIOR, DORGIVAL M. DE

; CARVALHO, FRANCISCO F.R. DE

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 2 elocation e20201412

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to evaluate the effect of increasing levels of spineless cactus (SC) [Nopalea cochenillifera (L.) Salm Dyck] on nutrient intake, ingestive behaviour, and performance of lambs in a feedlot. Thirty-two male (non-castrated) Santa Inês lambs with a mean initial body weight (BW) of 20.4 ± 2.60 kg were distributed across four levels of spineless cactus: zero, 24, 52, and 75% of total diet dry matter (DM). Over 56 days, the animals had their intake and performance monitored. The inclusion of SC influenced (p<0.05) in a quadratic way the dry matter intake and total digestible nutrients, but linearly decreased (p<0.05) the neutral detergent fiber intake. Drinking water intake decreased linearly (p<0.05) with the inclusion of SC in the diet. The inclusion of SC influenced (p<0.05) in a quadratic way the digestibility of organic matter in the diet. The increase in the level of SC in the diet increased linearly (p<0.05) the feeding and rumination efficiencies of the lambs. The maximum daily gain of 0.237 kg/day was achieved with 44% SC in the diet. It is recommended to include up to 40% of spineless cactus in the diet of lambs.

https://doi.org/10.1590/0001-3765202320201412

10.

Determinants of poor sleep quality in adults during the coronavirus disease pandemic: COVID-Inconfidentes, a population-based study
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Menezes Júnior, Luiz Antônio Alves de

; Lourenção, Luciano Garcia

; Andrade, Amanda Cristina de Souza

; Carraro, Júlia Cristina Cardoso

; Machado-Coelho, George Luiz Lins

; Meireles, Adriana Lúcia

Sao Paulo Medical Journal

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2023, Volume 141 Nº 4 elocation e2022139

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: The coronavirus disease (COVID-19) pandemic has adversely affected the health of the global population, with sleep quality being one of the affected parameters. OBJECTIVES: To evaluate sleep quality and its associated factors in adults during the COVID-19 pandemic in Brazil. DESIGN AND SETTING: A population-based cross-sectional serological survey of 1,762 adults in the Iron Quadrangle region of Brazil. METHODS: The Pittsburgh Sleep Quality Index was used to assess sleep quality. Sociodemographic variables, health conditions, health-related behaviors, anxiety, vitamin D levels, weight gain/loss, and pandemic characteristics were assessed using a structured questionnaire. Univariate and multivariate analyses using Poisson regression with robust variance were performed to identify factors associated with sleep quality. RESULTS: More than half of the participants reported poor sleep quality (52.5%). Multivariate analysis revealed that the factors associated with poor sleep quality included living alone (prevalence ratio [PR] = 1.34; 95% confidence interval [CI]: 1.04–1.73), anxiety disorder (PR = 1.32; 95% CI: 1.08–1.62), 5.0% weight loss (PR = 1.21; 95% CI: 1.02–1.44), 5.0% weight gain (PR = 1.27; 95% CI: 1.03–1.55), vitamin D deficiency (PR = 1.16; 95% CI: 1.01–1.35), and COVID-19 symptoms (PR = 1.29; 95% CI: 1.10–1.52). CONCLUSIONS: Our study revealed that more than half of the participants experienced poor sleep quality during the COVID-19 pandemic. Factors associated with poor sleep quality included vitamin D deficiency and weight changes related to the pandemic.

https://doi.org/10.1590/1516-3180.2022.0139.r1.19082022

11.

Intake, digestibility, and ingestive behavior of sheep fed with thornless Mandacaru, cactus pear genotypes Orelha de Elefante Mexicana and Miúda
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Silva, Maria Vitória Serafim da

; Aguiar, Emerson Moreira de

; Silva, José Geraldo Medeiros da

; Melo, Airon Aparecido Silva de

; Cardoso, Daniel Barros

; Costa, Marcone Geraldo

; Costa Filho, José Hamilton da

; Ramalho, Adriana Margarida Zanbotto

Acta Scientiarum. Animal Sciences

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2023, Volume 45 elocation e58162

Resumo: En | Texto: En | PDF: En

ABSTRACT. This study aimed to evaluate the intake, digestibility, and ingestive behavior of sheep fed with different species of forage cacti. Fifteen sheep (17.27kg ± 1 kg) were distributed in a completely randomized experimental design with three treatments and five replicates. The treatments were diets on a dry matter basis composed of 430.9 g kg-1 of thornless Mandacaru cactus (Cereus hildmannianus), 525.7 g kg-1 of cactus pear cv. Orelha de Elefante Mexicana (Opuntia stricta) and 492.1 g kg-1 of cactus pear cv. Miúda (Nopalea cochenillifera) in addition to Sabiá hay (Mimosa caesalpiniaefolia) (194.7 to 233.8 g kg-1), plus concentrate feed. The intake of the dry matter, organic matter, ether extract, neutral detergent fiber, total carbohydrates, non-fiber carbohydrates, total digestible nutrients and voluntary water intake in g day-1 was not differ (p > 0.05) by experimental diets. There were no differences (p > 0.05) in digestibility coefficients of the dry matter, organic matter, neutral detergent fiber, total carbohydrates, non-fiber carbohydrates, and total digestible nutrients between the experimental diets. The feeding times differed (p < 0.05) between diets, with a higher value for the Opuntia diet, while the rumination times, feeding efficiency, and rumination efficiency did not differ (p > 0.05). The cactus Cereus and Opuntia and Nopalea have similar nutritional value in sheep’s diet.

https://doi.org/10.4025/actascianimsci.v45i1.58162

12.

REPERCUSSÕES PSICOSSOCIAIS DO TRATAMENTO RADIOTERÁPICO PARA O CÂNCER DO COLO UTERINO: UMA ABORDAGEM QUALITATIVA
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Pimentel, Natalia Beatriz Lima

; Modesto, Felipe Cardoso

; Lima, Vivian Cristina Gama Souza

; Oliveira, Adriana Maria de

; Andrade, Karla Biancha Silva de

; Fuly, Patrícia dos Santos Claro

; Santos, Mauro Salvador Caldeira dos

Cogitare Enfermagem

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2023, Volume 28 elocation e83874

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to understand the psychosocial repercussions of post radiotherapy treatment for cervical cancer. Method: qualitative study, with the participation of patients in post radiotherapy treatment for cervical cancer in an onco-gynecologic nursing outpatient clinic, located in the Municipality of Rio de Janeiro - Brazil. Data were collected during the months of March and April 2019 by means of open interview and submitted to content analysis. Results: four categories were defined: the construct of social roles: the loss of female identity; the sexuality of post-treated women for cervical cancer: marital repercussions; difficulties in adapting to the new life condition: rebuilding the body image; living with cervical cancer: rethinking life and rebuilding values through the support network. Final considerations: the results contribute to the direction of care, increasing the quality of life and helping these women reorganize their professional, social, and family lives.

RESUMEN Objetivo: conocer las repercusiones psicosociales del tratamiento post-radioterapia del cáncer de cuello de útero. Método: estudio cualitativo, con la participación de pacientes en tratamiento post radioterapia para cáncer de cuello uterino en una consulta externa de enfermería oncoginecológica, ubicada en el Municipio de Río de Janeiro - Brasil. Los datos fueron recolectados durante los meses de marzo y abril de 2019 a través de una entrevista abierta y fueron sometidos a un análisis de contenido. Resultados: se definieron cuatro categorías: la construcción de los roles sociales: la pérdida de la identidad femenina; la sexualidad de las mujeres después del tratamiento del cáncer de cuello uterino: las repercusiones conyugales; las dificultades de adaptación a la nueva condición de vida: la reconstrucción de la imagen corporal; la convivencia con el cáncer de cuello uterino: el replanteamiento de la vida y la reconstrucción de los valores a través de la red de apoyo. Consideraciones finales: los resultados contribuyen a la orientación de los cuidados, aumentando la calidad de vida y ayudando a la reorganización de la vida profesional, social y familiar de estas mujeres.

RESUMO Objetivo: compreender as repercussões psicossociais do pós-tratamento radioterápico para o câncer do colo uterino. Método: estudo qualitativo, com a participação de pacientes em pós-tratamento radioterápico para o câncer do colo uterino em um ambulatório de enfermagem oncoginecológica, localizado no Município do Rio de Janeiro - Brasil. Os dados foram coletados durante os meses de março e abril de 2019 por meio de entrevista aberta e submetidos à análise de conteúdo. Resultados: definiram-se quatro categorias: o constructo de papéis sociais: a perda da identidade feminina; a sexualidade da mulher pós-tratamento para o câncer do colo uterino: repercussões conjugais; dificuldades de adaptação à nova condição de vida: reconstruindo a imagem corporal; convivendo com o câncer do colo uterino: repensando a vida e reconstruindo valores através da rede de apoio. Considerações finais: os resultados contribuem para o direcionamento do cuidado, aumentando a qualidade de vida e auxiliando a reorganização da vida profissional, social e familiar dessas mulheres.

https://doi.org/10.1590/ce.v28i0.83874

13.

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 2 elocation e20220151

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

14.

Carcass characteristics and meat quality of lambs fed diets with different roughage: concentrate ratios supplemented with liquid residue of cassava
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Guim, Adriana

; Silva, Karla Katiene de Souza

; Véras, Robson Magno Liberal

; Leite, Paulo Márcio Barbosa de Arruda

; Abreu, Karen Santos Félix de

; Cardoso, Daniel Barros

Acta Scientiarum. Animal Sciences

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2023, Volume 45 elocation e59105

Resumo: En | Texto: En | PDF: En

ABSTRACT. The objective of this study was to evaluatethe effects oflambs fed two roughage: concentrate (R:C) ratios, with or without the liquid residue of cassava (LRC)on carcass traits and meat quantity.Forty lambs (19.5 ± 1.45 kg body weight), non-castrated, crossbred Santa Inês were distributed in a completely randomized 2 × 2 factorial design. There was no effect (p > 0.05) of the inclusion of LRC on the variables. The roughage:concentrate ratio of 40:60 promoted higher values for empty body weight, hot carcass weight, cold carcass weight, subcutaneous thickness fat, cooling loss,Longissimusmuscle area, carcass morphometric measurements, and commercial cuts. Higher weight of leg, muscles, fat, bone and other tissues, as well as for the ratio muscle:fat, and muscle:bone was observed in lambs fed 40R:60C. For the meat chemical composition, there was the effect (p < 0.05) only for ether extract (EE) for lambs fed 40R:60C ratio. The redness (a*) of meat was greater (p < 0.05) for lambs fed 80R:20C. The other physicochemical characteristics were not influenced. The roughage:concentrate ratio of 40:60 improves the carcass traits and commercial cuts, but does not promote changes in meat quality, independent of supplementation with liquid residue of cassava.

https://doi.org/10.4025/actascianimsci.v45i1.59105

15.

Aging-related predictive factors for oxygenation improvement and mortality in COVID-19 and acute respiratory distress syndrome (ARDS) patients exposed to prone position: A multicenter cohort study
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Cunha, Marieta C.A.

; Schardong, Jociane

; Righi, Natiele C.

; Lunardi, Adriana C.

; Sant’Anna, Guadalupe N.

; Isensee, Larissa P.

; Xavier, Rafaela F.

; Pompeu, Jose E.

; Weigert, Renata M.

; Matte, Darlan L.

; Cardoso, Rozana A.

; Abras, Ana C.V.

; Silva, Antonio M.V.

; Dorneles, Camila C.

; Werle, Roberta W.

; Starke, Ana C.

; Ferreira, Juliana C.

; Plentz, Rodrigo D.M.

; Carvalho, Celso R.F.

Clinics

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2023, Volume 78 elocation 100180

Resumo: En | Texto: En | PDF: En

Abstract Background: Elderly patients are more susceptible to Coronavirus Disease-2019 (COVID-19) and are more likely to develop it in severe forms, (e.g., Acute Respiratory Distress Syndrome [ARDS]). Prone positioning is a treatment strategy for severe ARDS; however, its response in the elderly population remains poorly understood. The main objective was to evaluate the predictive response and mortality of elderly patients exposed to prone positioning due to ARDS-COVID-19. Methods: This retrospective multicenter cohort study involved 223 patients aged ≥ 65 years, who received prone position sessions for severe ARDS due to COVID-19, using invasive mechanical ventilation. The PaO2/FiO2 ratio was used to assess the oxygenation response. The 20-point improvement in PaO2/FiO2 after the first prone session was considered for good response. Data were collected from electronic medical records, including demographic data, laboratory/image exams, complications, comorbidities, SAPS III and SOFA scores, use of anticoagulants and vasopressors, ventilator settings, and respiratory system mechanics. Mortality was defined as deaths that occurred until hospital discharge. Results: Most patients were male, with arterial hypertension and diabetes mellitus as the most prevalent comorbidities. The non-responders group had higher SAPS III and SOFA scores, and a higher incidence of complications. There was no difference in mortality rate. A lower SAPS III score was a predictor of oxygenation response, and the male sex was a risk predictor of mortality. Conclusion: The present study suggests the oxygenation response to prone positioning in elderly patients with severe COVID-19-ARDS correlates with the SAPS III score. Furthermore, the male sex is a risk predictor of mortality.

https://doi.org/10.1016/j.clinsp.2023.100180

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